Hereditary Predispositions to Myelodysplastic Syndrome

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Hereditary Predispositions to Myelodysplastic Syndrome

Myelodysplastic syndromes (MDS) are heterogeneous clonal hematopoietic disorders characterized by ineffective hematopoiesis, bone marrow dysplasia, and peripheral cytopenias. Familial forms of MDS have traditionally been considered rare, especially in adults; however, the increasing availability of somatic and germline genetic analyses has identified multiple susceptibility loci. Bone marrow fa...

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Myelodysplastic syndrome.

The last decade has witnessed a multistep evolution in the understanding of the natural history, clinical manifestations, and some of the molecular mechanisms that underlie the ineffective hematopoiesis and leukemic transformation in the myelodysplastic syndrome (MDS). The international prognostic scoring system, FAB, and WHO classifications have helped define specific subgroups with their char...

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Myelodysplastic Syndrome

The hallmark of neoplastic disease, including myelodysplastic syndrome (MDS), is clonal proliferation of cells. Clonal proliferation is the consequence of acquired somatic mutation that confers a proliferative advantage to cells. For the myelodysplastic syndrome, the ability to identify clonally derived cells has provided valuable information about the molecular pathogenesis of the disease, the...

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Myelodysplastic syndrome.

During the past 15 years, important progress has been made in the understanding of the biology and prognosis of myelodysplastic syndrome (MDS). MDS is a clonal disorder characterized by ineffective hematopoiesis, which can lead to either fatal cytopenias or acute myelogenous leukemia (AML). Risk-adapted treatment strategies were established because of the high median age (60-75 years) of the MD...

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ژورنال

عنوان ژورنال: International Journal of Molecular Sciences

سال: 2016

ISSN: 1422-0067

DOI: 10.3390/ijms17060838